Facultad de Medicina · 2026
Narrative Review: Umbilical Cord-Derived Mesenchymal Stem Cells and Osteoarthritis
Solo ficha. El repositorio marca este trabajo como «Acceso abierto»: el PDF no es público, así que aquí no hay texto para leer. Ver la ficha en el repositorio.
Resumen
Osteoarthritis (OA) is the leading cause of articular pain in adult patients, with a high worldwide prevalence and a trend towards increasing. By 2050, 642 million people are expected to suffer from knee OA. Current treatment focuses on measures to prevent progressive joint wear and control symptoms such as pain. Research in regenerative medicine, including the infiltration of platelet-rich plasma, has not yet provided solid evidence for its efficacy. With the advent of cellular therapy, the isolation and expansion of mesenchymal stem cells (MSCs) from various origins have shown promise in reducing inflammation and creating a suitable environment for the regeneration of articular cartilage. This narrative review focuses on umbilical cord-derived mesenchymal stem cells (UC-MSCs), which have certain advantages over other types of MSCs. It summarizes the various clinical trials conducted in recent years, based on a search of multiple databases.