Química Farmacéutica · 2019

Caracterización de reacciones adversas de medicamentos derivados de enzimas ocurridas en Bogotá D. C. durante el periodo 2008-2018

One of the most important advances in modern medicine is the development of molecular biology with an emphasis on genetics, the advance has been so important that today enzymes can be isolated, such as agalsidase Alfa, agalsidase Beta, Alglucosidase, Asparaginase, Streptokinase, Idursulfase, Imiglucerase, Laronidase and Tenecteplase. These drugs are used for enzymatic, antineoplastic and thrombolytic replacement therapy, for which it is necessary to conduct a pharmacovigilance study, in which the different adverse reactions to them were analyzed. The information collected were 231 cases, in which they presented 4 PRM and 227 RAM, the highest incidence occurs in men, where a significant number of cases are in an age range between 0 to 5 years old. In most cases, reactions associated with an immune response were determined. 7

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